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系所資訊
特聘教師

Hirohiko Tsujii, MD, PhD   

               

 Present Positions:

Deputy Director, QST Hospital, National Institute for Quantum and Radiological Science and Technology (QST)

Director, International Particle Therapy Research Center, QST Hospital, National Institute for Quantum and Radiological Science and Technology (QST)

Vice President, Association for Nuclear Technology in Medicine (Non-profit Foundation) Director, Particle Radiotherapy Consultation Clinic

Visiting Professor, THOTO College of Health Sciences

Specialty: Radiation Oncology

 

 Major Research Interests:

  1. Charged particle radiotherapy and high-precision radiotherapy
  2. Carbon-ion radiotherapy
  3. Hypofractionated radiotherapy
  4. Dose fractionation and biological model
  5. Radiotherapy for photon-resistant malignancies

 

 Education and Training:

1962-68

Hokkaido University School of Medicine, Japan

1968-69

Intern, Hokkaido University Hospital, Japan

1972-74

Resident, Department of Radiotherapy

St. Vincent Hospital and Medical Center of New York, U.S.A.

1978-79

Research fellow, The University of New Mexico, U.S.A.

1982-83

Research fellow, Paul Schaeller Institute, Switzerland

 

 Licensure and Certification:

 

1968

Japanese Board of Medicine, Japan (No. 20051)

1971

Educational Council for Foreign Medical Graduate (ECFMG, No 1482645)

1975

Type-1 Radiation Protection Supervisor (No.6017)

1966

Diploma in Physics (M. Sc.)

1985

Dr. Med (M.D.), Hokkaido University School of Medicine (No. 2859)

2009

Life certified physician, JASTRO

2012

Certified Occupational Physician (No. 1200978)

 Professional Appointments:

 

1969-72

Medical Staff Junior, Department of Radiology, Sapporo Cancer Center, Japan

1972-74

Resident, Department of Radiotherapy, Japan

St. Vincent Hospital and Medical Center of New York, U.S.A.

1974-85

Lecturer, Department of Radiology, Hokkaido University School of Medicine

1985-88

Associate Professor, Department of Radiology,

Hokkaido University School of Medicine

1988-89

Associate Professor, Tsukuba University

1989-94

Professor and Director, Proton Medical Research Center (PMRC),

Tsukuba University

1994-03

Director, Research Center Hospital for Charged Particle Therapy,

National Institute of Radiological Sciences (NIRS)

1999-01

Director, Department of Radiation Health, NIRS

2005-06

Director, Molecular Imaging Center, National Institute of Radiological Sciences

(NIRS)

2003-08

Director, Research Center for Charged Particle Therapy, National Institute of

Radiological Sciences (NIRS)

2008-11

Executive Director, National Institute of Radiological Sciences (NIRS)

2011-15

Special Advisor, Saga Ion Medical Center (SAGA HIMAT)

2011-18

Visiting Researcher, National Institute of Radiological Sciences (NIRS)

2011-present

  Vice President, Association for Nuclear Technology in Medicine

 

  Director, Particle Radiotherapy Consultation Clinic

2016-19 

  Director, Ion-Beam Radiation Oncology Center in Kanagawa (iROCK), KCC

2018-present    Deputy Director, QST Hospital, National Institute for Quantum and 
  Radiological Science and Technology (QST)

 

  Director, International Particle Therapy Center, QST Hospital, National Institute
  for Quantum and Radiological Science and Technology (QST)


 

 

 Honors and Awards:

2001

Honorary membership, ESTRO

2001

Secretary General, Japan Society for Therapeutic Radiology and Oncology (JASTRO)

2004

President, Japan Society for Therapeutic Radiology and Oncology (JASTRO)

2005

Scientific Award, Princess Takamatsu Cancer Research Fund, Japan

2006

Scientific Award, National Institute of Science and Technology Policy, Japan

2006

Coordinate Member, The Science Council of Japan

2006

Honorable Award, National Institute of Radiological Sciences

2006

Chairman, Particle Therapy Cooperative Group (PTCOG)

2013

Gold Medal, JASTRO

2015

The Order of the Sacred Treasure, Gold Rays with Neck Ribbon, Japan

2015

Culture, Sports, Science and Technology Minister's Award

 

 Academic Appointments:

1995-16        Project Leader, Forum for Nuclear Cooperation in Asia (FNCA), Japan

1995-97        International Advisory Board Member, Gesellschaft für Schwerionenforschung (GSI), Germany

2005-10        Visiting Professor, Chiba University School of Medicine, Japan

2005-15        Visiting Professor, Gunma University Graduate School of Medicine, Japan

2005-06        Advisory Panel Member, Report on the OSUMC Hadron Therapy Design, Ohio State University Medical Center, U.S.A.

2006-07        Visiting Professor, Mayo Clinic, USA

2007-18        Visiting Professor, Kitasato University School of Medicine, Japan

2009-10        IAEA Technical Co-operation Expert, The Project of Establishing the King Abdullah Oncology Centre, Saudi Arabia

2009-13        International Advisory Committee Member, National Laboratory of Heavy Ion Research Facility in Lanzhou (HIRFL--IAC), Institute of Modern Physics (IMP), China

2010-11        Visiting Professor, National Centre of Oncological Hadrontherapy (CNAO), Italy 2010-11     Visiting Professor, Sun Yat-sen University, China

2010-13        Co-chairman, ICRU Report on Prescribing, Recording and Reporting Ion-Beam Therapy, Switzerland

2012-14        ICRP Task Group Member, Annals of the ICRP - Radiological Protection in Ion Beam Radiotherapy, Switzerland

2012-13        Professional Consultant, National Centre of Oncological Hadrontherapy (CNAO), Italy

2013-14        Visiting Professor, Shanghai Proton and Heavy Ion Center (SPHIC), China 2013      Invited Lecturer, MedAustron, Austria

2013-17        Course Director, 1st to 6th International Training Course on Carbon Ion Radiotherapy (ITCCIR), Japan

2014-15        International Advisory Committee Member, Medical Applications Initiatives Coordination, CERN, Switzerland

2014-16        Medical Consultant, Best Medical International Inc., U.S.A.

2014-17        Special Advisor, Heavy Ion Working Group, Okinawa Prefecture, Japan

2015-16        Technical Consultant, UT Southwestern’s Proposal to establish Heavy Ion Therapy & Research Center, UTSW, U.S.A

2018             Co-chairman, 5th International Symposium on Ion Therapy (ISIT2018), Japan 

2011-Present          Visiting Professor, THOTO College of Health Sciences, Japan

 Membership:

Japan Society for Therapeutic Radiology and Oncology (JASTRO) Japan Radiological Society (JRS)

Japan Society of Clinical Oncology Japan Isotope Association
Japanese Cancer Association

Particle Therapy Cooperative Group (PTCOG)

American Society for Therapeutic Radiology and Oncology (ASTRO)

American Society of Clinical Oncology (ASCO)

 Recent Invited Presentations and Lectures:

2019 (6 talks), 2018 (15 talks), 2017 (28 talks), 2016 (26 talks), 2015 (39 talks), 2014 (34 talks),

2013 (48 talks), 2012 (30 talks), 2011 (38 talks), 2010 (29 talks)

 Recent Major Publications:

  1. Yamamoto N, Miyamoto T, Nakajima M, et al.: A dose escalation clinical trial of single-fraction carbon-ion radiotherapy for peripheral Non-small cell lung cancer. J Thoracic Oncol. 12(4), 673-680, 2017
  2. Koto M, Hasegawa A, Takagi R, et al.: Definitive carbon-ion radiotherapy for locally advanced parotid gland carcinomas. Head & Neck 10.1002/hed. 24671, 2016
  3. Shinoto M, Yamada S, Terashima K, et al.: Carbon ion radiotherapy with concurrent Gecitabine for patients with locally advanced pancreatic cancer. Radiother Oncol. 95(1), 498-504, 1016
  4. Kamada T, Tsujii H, Blakeley EA, Debus J, De Neve, W, Durante M, Jaekel O, Mayer R, Orecchia R, Poetter R, Vatnisky S, Chu WT: Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience. The Lancet Oncology Vol. 16, No.2, e93-e100, 2015
  5. Tsujii H, Kamada T, Shirai T, et al (eds): Carbon-Ion Radiotherapy; Principles, Practices and Treatment Planning. Springer Japan, 2014.
  6. Tsujii H, and Kamada T: A review of update clinical results of carbon ion radiotherapy. Jpn. J Clin. Oncol. 42(8), 670-685, 2012
  7. Kamada T, Tsujii H : HIMAC: A new start for heavy ions. In: Ion Beam Therapy (Ed by Linz U). Springer-Verlag Berlin Heidelberg, pp611-621, 2011
  1. Jingu K, Kishimoto R, Mizoe J, et al : Malignant mucosal melanoma treated with carbon ion radiotherapy with concurrent chemotherapy: Prognostic value of pretreatment apparent diffusion coefficient (ADC), Radiother Oncol. 98(1), 68-73, 2011
  2. Imada H, Kato H, et al : Comparison of efficacy and toxicity of short-course carbon ion radiotherapy for hepatocellular carcinoma depending on their proximity to the porta hepatis. Radiother Oncol. 96: 231-235, 2010
  3. Mizoe J, Hasegawa A, Takagi S, et al: Carbon Ion Radiotherapy for Skull Base Chordoma, Skull Base : An Interdisciplinary Approach. Int J Radiat Oncol Biol Phys, 19(3), 219-224, 2009
  4. Sugane T, Miyamoto T, et al: Carbon ion radiotherapy for elderly patients 80 years and older with stage I non-small cell lung cancer. Lung Cancer, 64(1), 45-50, 2009
  1. Yoshiyuki Suzuki, et al: Prognostic Impact of Mitotic Index of Proliferating Cell Populations in Cervical cancer Patients Treated With Carbon Ion Beam, Cancer, 115(9), 1875-1882, 2009,
  1. Kazunori Nojiri, et al: The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation. Experimental Biology and Medicine (Maywood, N.J.), 234(1), 112-122, 2009
  1. Tomoaki Tamaki, et al: Application of Carbon Ion Beams or Gamma-Rays on Primary Tumors Does Not Change the Expression Profiles of Metastatic Tumors in an in vivo Murine Model. Int J Radiat Oncol Biol Phys, 74(1), 210-218, 2009
  1. Takeshi Yanagi, Junetsu Mizoe, Azusa Hasegawa, et al: Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy, Int J Radiat Oncol Biol Phys, 74(1),15-20, 2009
  2. Tsujii H, Noda K, et al: Heavy-Particle Radiotherapy: System Design and Application. Reviews of Accelerator Science and Technology. World Scientific Publishing Company, Vol. 2 : 1–18, 2009
  3. Tsujii H, Kamada T, Baba M, et al :Clinical advantages of carbon-ion radiotherapy. New J Phys. 10: 1367-2630, 2008
  4. Schulz –Ertner, D., and Tsujii, H : Particle radiation therapy using proton and heavier ion beams. J Clin Oncol 25(8), 953-964, 2007
  5. Tsuji, H., Ishikawa, H., Yanagi, T., et.al : Carbon-ion radiotherapy for Locally advanced or unfavorably located choroidal melanoma: A Phase I/II Dose Escalation Study. Int J Radiat Oncol Biol Phys 67, 857-862, 2007
  1. Takashi Nakano*, Yoshiyuki Suzuki*, Tatsuya Ohno, Shingo Kato, Michiya Suzuki, Shinroku Morita, Shinichirou Satou, Kuniyuki Oka*, Hirohiko Tsujii: Carbon beam therapy overcomes hypoxia-originating radiation-resistant nature of uterine cervical cancer., Clinical Cancer Research, in press, 000, 2006
  1. Shinichirou Mori, Masahiro Endo, Takayuki Obata, Riwa Kishimoto, Hirotoshi Katou, Susumu Kandatsu, Hirohiko Tsujii, Shuji Tanada: Noise Properties for Three Weighted Feldkamp Algorithms Using a 256-Detecotor Row CT-Scanner: Case Study for Hepatic Volumetric Cine Imaging, European Journal of Radiology, 000, 2006
  1. Tatsuya Ohno, Shingo Kato, Masaru Wakatuki, Shinei Noda, Chiemi Murakami, Misako Nakamura, Hirohiko Tsujii: Incidence and temporal pattern of anorexia, diarrhea, weight loss,and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone., Gynecologic Oncology, in press, 000, 2006
  1. Yoshiyuki Suzuki*, Takashi Nakano*, Tatsuya Ohno, Shingo Kato, Yuzuru Niibe*, Shinroku Morita, Hirohiko Tsujii: Oxygenated and reoxvgenated tumors show better local control in radiation therapy for cervical cancer., International Journal of Gynecological Cancer, 16(1), 306-311, 2006
  1. Azusa Hasegawa, Junetsu Mizoe, Atsushi Mizota, Hirohiko Tsujii: Outcomes of visual acuity in carbon ion radiotherapy:analysis of dose-volume histograms and prognostic factors, International Journal of Radiation Oncology Biology Physics, 64(2), 396-401, 2006
  1. Wataru Noguchi*, Tatsuya Ohno, Okihiko Aihara*, Hirohiko Tsujii, et.al: Spiritual needs in cancer patients and spiritual care based on logotherapy., Supportive Care in Cancer, 14(1), 65-70, 2006
  1. Shinichirou Mori, Takayuki Obata, Riwa Kishimoto, Hirotoshi Katou, Kenya Murase, Susumu Kandatsu, Shuji Tanada, Hirohiko Tsujii, Masahiro Endo: Clinical Potentials for Dynamic Contrast-enhanced Hepatic Volumetric Cine Imaging with the Prototype 256- MDCT scanner, American Journal of Roentgenology, 185, 253-256, 2005
  1. Kurnia Lin*, Tatsuya Ohno, Shingo Kato, Hidefumi Ezawa, Junko Noguchi, Hirohiko Tsujii: Histopathological radiation effect and MIB-1 expression in cervical cancer: comparison of early response by radiotherapy with or without cisplatin, Austral-Asian Journal of Cancer, 4(4), 201-204, 2005
  1. Mayumi Iwakawa, Miyako Gotou, Shuhei Noda, Masashi Sagara, Shigeru Yamada, Naohito Yamamoto, Yoshihiro Kawakami, Yoshifumi Matsui, Yukimasa Miyazawa, Hideya Yamazaki, Hiroshi Tsuji, Tatsuya Ohno, Junetsu Mizoe, Hirohiko Tsujii, Takashi Imai: DNA repair capacity measured by high throughput alkaline comet assays in EBV- transformed cell lines and peripheral blood cells from cancer patients and healthy volunteers, Genetic Toxicology and Environmental Mutagenesis : A Section of Mutation Research, 588, 1-6, 2005
  1. Hitoshi Shibuya*, Hirohiko Tsujii: THE STRUCTURAL CHARACTERISTICS OF RADIATION ONCOLOGY IN JAPAN IN 2003, International Journal of Radiation Oncology Biology Physics, 62(5), 1472-1476, 2005
  1. Hiroshi Tsuji, Takeshi Yanagi, Hitoshi Ishikawa, Tadashi Kamada, Junetsu Mizoe, Tatsuaki Kanai, Shinroku Morita, Hirohiko Tsujii: Hypofractionated radiotherapy with carbon ion beams for prostate cancer, International Journal of Radiation Oncology Biology Physics, 63(4), 1153-1160, 2005
  1. Shingo Kato, Tatsuya Ohno, Hirohiko Tsujii, Takashi Nakano*, Junetsu Mizoe, Tadashi Kamada, Tadaaki Miyamoto, Hiroshi Tsuji, Hirotoshi Katou, Shigeru Yamada, Susumu Kandatsu, Kyosan Yoshikawa, Hidefumi Ezawa, Michiya Suzuki: Dose Escalation study of Carbon Ion Radiation for Locality Advanced Carcinoma of the Cervik, International Journal of Radiation Oncology Biology Physics, in press, 000, 2005
  1. Masao Ootou, Hirotoshi Katou, Hirohiko Tsujii, Hitoshi Maruyama*, Shouichi Matsutani*, Hitoshi Yamagata*: Vascular Flow Patterns of Hepatic Tumors in Contrast-Enhanced Three-Dimensional Fusion Ultrasonography Using Plane Shift and Opacity Control Modes, Journal of Ultrasound in Medicine, 24(1), 49-57, 2005
  1. Hiroko Koyama-Ito, Masahiro Endo, Akira Ito*, Junetsu Mizoe, Hirohiko Tsujii: DESIGN AND IMPLEMENTATION OF A RADIOTHERAPY DATABASE IN CARBON ION THERAPY. Journal of JASTRO, 17(3), 161-168, 2005
  1. Takuya Morimoto, Takayuki Obata, Tatsuya Ohno, Yoshiyuki Suzuki, Hiroo Ikehira, Tetsuya Suhara, Shigeo Furukawa, Hirohiko Tsujii, Takashi Nakano*: Phosphorous-31 magnetic resonance spectroscopy of cervical cancer using transvaginal surface coil, Magnetic Resonance in Medical Sciences, 4(4), 000, 2005
  1. Riwa Kishimoto, Junetsu Mizoe, Syuhei Komatu, Susumu Kandatsu, Takayuki Obata, Hirohiko Tsujii: MR Imaging of Brain Injury Induced by Carbon Ion Radiotherapy for Head and Neck Tumors, Magnetic Resonance in Medical Sciences, 4(4), 159-164, 2005
  1. Takashi Nakano*, Shingo Kato, Tatsuya Ohno, Hirohiko Tsujii, Shinichirou Satou, Kenjirou Fukuhisa, Tatsuo Arai: Long-term Results of High-Dose-Rate Intracavitary Brachytherapy for Squamous Cell Carcinoma of the Uterine Cervix. Cancer, Cancer, 103(1), 92-101, 2004
  1. Hong Zhang, Kyosan Yoshikawa, Katsumi Tamura, Takashi Tomemori, Kenji Sago, Tian Mei*, Susumu Kandatsu, Tadashi Kamada, Hiroshi Tsuji, Tetsuya Suhara, Kazutoshi Suzuki, Shuji Tanada, Hirohiko Tsujii: 11C-Methionine Positron Emission Tomography and Survival in Patients with Bone and Soft Tissue Sarcomas Treated by Carbon Ion Radiotherapy, Clinical Cancer Research, 10, 1764-1772, 2004
  1. Reiko Imai, Tadashi Kamada, Hiroshi Tsuji, Takeshi Yanagi, Masayuki Baba, Tadaaki Miyamoto, Shingo Kato, Susumu Kandatsu, Junetsu Mizoe, Hirohiko Tsujii, et.al: Carbon Ion Radiotherapy for Unresectable Sacral Chordomas, Clinical Cancer Research, 10, 5741-5746, 2004
  1. Gaku Oohira, Shigeru Yamada, Takenori Ochiai*, Hisahiro Matsubara*, Shin-ichi Okazumi*, Koichi Ando, Hirohiko Tsujii, Hideaki Shimada*: Growth suppression of esophageal squamous cell carcinoma induced by heavy carbon-ion beams combined with p53 gene transfer, International Journal of Oncology, 25, 563-569, 2004
  1. Hirotoshi Katou, Hirohiko Tsujii, Tadaaki Miyamoto, Junetsu Mizoe, Tadashi Kamada, Hiroshi Tsuji, Shigeru Yamada, Susumu Kandatsu, Kyosan Yoshikawa, Takayuki Obata, Hidefumi Ezawa, Shinroku Morita, et.al: Results of the First Prospective Study of  Carbon Ion Radiotherapy for Hepatocellular Carcinoma with Liver Cirrhosis (in press), International Journal of Radiation Oncology Biology Physics, 59(5), 1468-1476, 2004
  1. Yoshiyuki Suzuki*, Takashi Nakano*, Shingo Kato, Tatsuya Ohno, Hirohiko Tsujii, Kuniyuki Oka*: Immunohistochemical Study of Cell Cycle-associated Proteins in Adenocarcinoma of the Uterine Cervix Treated with Radiotherapy Alone:p53 Status Has a Storong Impact on Prognosis, International Journal of Radiation Oncology Biology Physics, 60(1), 231-236, 2004
  1. Junetsu Mizoe, Hirohiko Tsujii, Tadashi Kamada, Yoshisuke Matsuoka*, Hiroshi Tsuji, Yasuhiro Osaka*, Azusa Hasegawa, Nobuharu Yamamoto, Satoshi Ebihara*, Akiyoshi Konno*, et.al: Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer, International Journal of Radiation Oncology Biology Physics, 60(2), 358-364, 2004
  1. Ryonfa Lee, Shigeru Yamada, Naoyoshi Yamamoto, Tadaaki Miyamoto, Koichi Ando, Marco Durante*, Hirohiko Tsujii: Chromosomal Aberrations in Lymphocytes of Lung Cancer Patients Treated with Carbon Ions, Journal of Radiation Research, 45(2), 195-199, 2004
  1. Takayuki Obata, Koichi Ando, Sachiko Koike, Chisa Oohira*, Hiroshi Yasuda, Hiroo Ikehira, Shuji Tanada, Hirohiko Tsujii: Changes in the pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation: Comparison with gamma-ray Radiation, Journal of Radiation Research, 45(2), 261-267, 2004
  1. Masashi Koto*, Tadaaki Miyamoto, Naoyoshi Yamamoto, Hideki Nishimura, Syougo Yamada*, Hirohiko Tsujii: Local control and recurrence of stage I non-small cell lung cancer after carbon ion radiotherapy, Radiotherapy and Oncology, 71, 147-156, 2004
  1. Hirohiko Tsujii, Junetsu Mizoe, Tadashi Kamada, Masayuki Baba, Shingo Kato, Hirotoshi Katou, Hiroshi Tsuji, Shigeru Yamada, Shigeo Yasuda, Tatsuya Ohno, Takeshi Yanagi, Azusa Hasegawa, Toshiyuki Sugawara, Hidefumi Ezawa, Susumu Kandatsu, Kyosan Yoshikawa, Riwa Kishimoto, Tadaaki Miyamoto: Overview of Clinical Experiences on Carbon Ion Radiotherapy at NIRS, Radiotherapy and Oncology, 73(Suppl.2), 41-49, 2004
  1. Hong Zhang, Kyosan Yoshikawa, Katsumi Tamura, Kenji Sagou, Tian Mei*, Tetsuya Suhara, Susumu Kandatsu, Kazutoshi Suzuki, Shuji Tanada, Hirohiko Tsujii: Carbon - 11-methionine positron emission tomography imaging of chordoma, Skeletal Radiology, 33(9), 524-530, 2004
  1. Wataru Noguchi*, Tatsuya Ohno, Satoshi Morita*, Okihiko Aihara*, Hirohiko Tsujii, Koujirou Simoduma*, Eisuke Matsushima*: Reliability and validity of the Functional Assessment of Chronic Illness Therapy-Spiritual (FACIT-Sp) for Japanese patients with cancer, Supportive Care in Cancer, 12(4), 240-245, 2004
  1. Yoshikazu Aoka*, Tadashi Kamada, Hirohiko Tsujii, et.al: Primary cardiac angiosarcoma treated with carbon-ion radiotherapy, The Lancet Oncology, 5(10), 636- 638, 2004
  1. Kouichirou Akakura*, Hirohiko Tsujii, Shinroku Morita, Hiroshi Tsuji, Tsuguo Yagishita*, Shigeo Isaka*, Haruo Itou*, Hideyuki Akaza*, Makoto Hata*, Shin Fujime*Masaoki Harada*, Jun Shimazaki*: Phase I/II Clinical Trials of Carbon Ion Therapy for Prostate Cancer, The Prostate, 58, 252-258, 2004
  1. Haruo Yoshida*, Toshimitsu Kobayashi*, Minoru Morikawa*, Kuniaki Hayashi*, Hirohiko Tsujii, Yasuhito Sasaki: CT imaging of the patulous eustachian tube - comparison between sitting and recumbent positions, Auris Nasus Larynx, (30), 135-140, 2003
  1. Toshiyasu Hirama, Sakae Tanosaki*, Susumu Kandatsu, Norikazu Kuroiwa, Tadashi Kamada, Hiroshi Tsuji, Shigeru Yamada, Hirotoshi Katou, Naoyoshi Yamamoto, Hirohiko Tsujii, Gen Suzuki*, Makoto Akashi: Initial medical management of patients severely irradiated in the Tokai-mura criticality accident, British Journal of Radiology, 76, 246-253, 2003
  1. Syohei Koyama*, Hirohiko Tsujii: Proton Beam Therapy with High-Dose Irradiation for Superficial and Advanced Esophageal Carcinomas, Clinical Cancer Research, 9, 3571-3577, 2003
  1. Nobuharu Yamamoto, Junetsu Mizoe, Azusa Hasegawa, Hirohiko Tsujii, et.al: Primary sebaceous carcinoma of the lacrimal gland treated by carbon ion radiotherapy., International Journal of Clinical Oncology, 8(6), 386-390, 2003
  1. Yuzuru Niibe*, Takashi Nakano*, Tatsuya Ohno, Yoshiyuki Suzuki*, Kuniyuki Oka*, Hirohiko Tsujii: Prognostic significance of c-erbB-2/HER2 expression in advanced uterine cevical carcinoma with para-aortic lymph node metastasis treated with radiation therapy, International Journal of Gynecological Cancer, 13, 849-855, 2003
  1. Shinichi Minohara, Masahiro Endo, Tatsuaki Kanai, Hirotoshi Katou, Hirohiko Tsujii: Estimating Uncertainties of the Geometrical Range of particle Radiotherapy during Respiration, International Journal of Radiation Oncology Biology Physics, 56(1), 121- 125, 2003
  1. Naoyoshi Yamamoto*, Tadaaki Miyamoto, Hideki Nishimura*, Masashi Koto*, Hirohiko Tsujii, Hidemi Owada*, Takehiko Fujisawa*: Preoperative carbon ion radiotherapy foy non-small cell lung cancer with chest wall invasion-pathological findings concerning tumor response and radiation induced lung injury in the resected organs., Lung Cancer, 42, 87-95, 2003
  1. Nobuharu Yamamoto, Junetsu Mizoe, Hideyuki Numasawa*, Hirohiko Tsujii, Takahiko Shibahara*, Hiroyasu Noma: Allelic loss on chromosomes 2q, 3p and 21q: Possibly a poor prognostic factor in oral squamous cell carcinoma., Oral Oncology, 39(8), 796-805, 2003
  1. Nobuharu Yamamoto, Junetsu Mizoe, Hideyuki Numasawa*, Hidetaka Yokoe*, Katsuhiro Uzawa*, Takahiko Shibahara*, Hirohiko Tsujii, Hiroyasu Noma*, Hideki Tanzawa*: Allelic loss of chromosome 2 in human oral squamous cell carcinoma: correlation with lymph node metastasis., Oral Oncology, 39, 64-68, 2003
  1. Hidefumi Ezawa, Ryuichi Yoneyama, Susumu Kandatsu, Kyosan Yoshikawa, Hirohiko Tsujii, Kenichi Harigaya*: Introduction of Autopsy Imaging (AI) Redefines the Concept of Autopsy: 37 Cases of Clinical Experience., Pathology International, 53(12), 865-873, 2003
  1. Tadaaki Miyamoto, Naoyoshi Yamamoto*, Hideki Nishimura*, Masashi Koto*, Hirohiko Tsujii, Junetsu Mizoe, Tadashi Kamada, Hirotoshi Katou, Shigeru Yamada, Shinroku Morita, Kyosan Yoshikawa, Susumu Kandatsu, Takehiko Fujisawa*: Carbon ion radiotherapy for stage I non-small cell lung cancer, Radiotherapy and Oncology, 66, 127-140, 2003
  2. Tadashi Kamada, Hirohiko Tsujii, Hiroshi Tsuji, Takeshi Yanagi, Junetsu Mizoe, Tadaaki Miyamoto, Hirotoshi Katou, Shigeru Yamada, Shinroku Morita, Kyosan Yoshikawa, Susumu Kandatsu, Akio Tateishi*: Efficacy and Safety of Carbon Ion Radiotherapy in Bone and Soft Tissue Sarcomasin Bone and Soft Tissue SarcomasIon Radiotherapy in Bone andSoft Tissue Sarcomas, Journal of Clinical Oncology, 20, 4466- 4471, 2002
  1. Shigeatsu Motoori*, Hideyuki Majima*, Masaaki Ebara*, Hirotoshi Katou, Futoshi Hirai, Shizuko Kakinuma, Chizuru Tsuruoka, Toshihiko Ozawa, Tetsuo Nagano*, Hirohiko Tsujii, Hiromitsu Saisho*: Overexpression of Mitochondorial Manganese Superoxide Dismutanse Protects against Radiation-induced Cell Death in the Human Hepatocellular Carcinoma Cell Line HLE. , Cancer Research, 61, 5382-5388, 2001
  1. Yasuo Iwadate*, Junetsu Mizoe, Yasuhiro Osaka*, Akira Yamaura*, Hirohiko Tsujii: High Linear Energy Transfer Carbon Radiation Effectively Kills Cultured Glioma Cells with Either Mutant or Wild-type p53, International Journal of Radiation Oncology Biology Physics, 50, 803-808, 2001
  1. Hideki Nishimura*, Tadaaki Miyamoto, Naoyoshi Yamamoto, Masashi Kotou, Kazurou Sugimura*, Hirohiko Tsujii: Assessment of pulmonary rection after corbon ion irradiation in the patients with stage I non-small cell lung cancer, International Journal of Radiation Oncology Biology Physics, 51(3), 358-359, 2001
  1. Makoto Akashi, Toshiyasu Hirama, Sakae Tanosaki*, Norikazu Kuroiwa, Kenichi Nakagawa, Hiroshi Tsuji, Hirotoshi Katou, Shigeru Yamada, Tadashi Kamada, Tatsuya Kinugasa*, H Ariga*, Kazuhiko Maekawa*, Gen Suzuki*, Hirohiko Tsujii: Initial symptoms of acute radiation syndrome in the JCO criticality accident in Tokai-mura., Journal of Radiation Research, 42, 157-166, 2001
  1. Hiroaki Onaya*, Yuji Itai*, Dai Yoshioka*, Takashi Akagi, Mamoru Niitsu*, Toshiyuki Okumura*, Yasuyuki Akine*, Yasushi Matuzaki*, Masahiro Doi, Hirohiko Tsujii: Changes in the liver parenchyma after proton beam radiotherapy :evaluatiion with MR imaging, Magnetic Resonance Imaging, 18, 707-714, 2001
  1. Hiroaki Onaya*, Yuji Itai*, Takashi Akagi, Dai Yoshioka*, Toshiyuki Okumura*, Yasuyuki Akine*, Hiroshi Tsuji, Hirohiko Tsujii: Recurrent hepatocellular carcinma versus radiation-induced hepatic injury-differential diagnosis with MR imaging, Magnetic Resonance Imaging, 19, 41-46, 2001
  1. Shigeru Yamada, Marco Durante*, Koichi Ando, Yoshiya Furusawa, Tetsuya Kawata*, Hideyuki Majima, Hirohiko Tsujii: Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity, Cancer Letters, 150, 215-221, 2000
  2. Marco Durante*, Shigeru Yamada, Koichi Ando, Yoshiya Furusawa, Tetsuya Kawata, Hideyuki Majima, Takashi Nakano, Hirohiko Tsujii: X-Rays VS. Carbon-Ion Tumor Therapy: Cytogenetic Damage in Lymphocytes, International Journal of Radiation Oncology Biology Physics, 47(3), 793-798, 2000